The CMGC super family of proline-directed protein kinases is a highly conserved and ancient group of proteins that phosphorylate a wide array of substrates involved in stress response, growth and differentiation, and cell division cycle.

As an integral part of the machinery of cellular function, proteins undergo regulation by a variety of post-translational modifications. One of the most prevalent and widely studied PTMs is Serine/Threonine phosphorylation. A few prominent kinases